In the process of bottom water reservoir development, bottom water coning leads to the problem of increasing water content in production wells. A three-dimensional vertical-well reservoir physical simulation device was established, and was used to study the nitrogen injection for controlling bottom water coning. The influencing rules of nitrogen injection timing, injection rate, injection volume and shut-off time were studied. The research shows that the production wells to injection of nitrogen in bottom water reservoir can effectively reduce the produced liquid water content, prolong production time, so as to achieve the effect of stabilizing oil production by control of the bottom water coning. When the nitrogen injection was carried out, the injection rate of nitrogen had little effect on the water control effect, and the injection rate of nitrogen and the time after the injection of gas had a great influence on the effect of water control.